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Bactericidal activity of fosfomycin and linezolid administered simultaneously or sequentially against <t>mrsa</t> in Static-concentration time- kill studies. Different dose, <t>(A)</t> <t>43300</t> 1 × mic fos + 0.5 × mic lzd (B) 43300 0.5 × mic fos + 1 × mic lzd (C) 43300 1 0.5 × mic fos + 0.5 × mic lzd (D) Isolate 1 1 1 × mic fos + 0.5 × mic lzd (E) Isolate 1 0.5 × mic fos + 1 × mic lzd (F) Isolate 1 0.5 × mic fos + 0.5 × mic lzd (G) Isolate 2 1 × mic fos + 0.5 × mic lzd (H) Isolate 2 0.5 × mic fos + 1 × mic lzd (I) Isolate 2 0.5 × mic fos + 0.5 × mic lzd (J) Isolate 3 1 × mic fos + 0.5 × mic lzd (K) Isolate 3 0.5 × mic fos + 1 × mic lzd (L) Isolate 3 0.5 × mic fos + 0.5 × mic lzd. Control: no drug; 0 h, concurrent administration group; 2 h, 4 h, 6 h, 8 h, sequential administration group, interval time.
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Bactericidal activity of fosfomycin and linezolid administered simultaneously or sequentially against <t>mrsa</t> in Static-concentration time- kill studies. Different dose, <t>(A)</t> <t>43300</t> 1 × mic fos + 0.5 × mic lzd (B) 43300 0.5 × mic fos + 1 × mic lzd (C) 43300 1 0.5 × mic fos + 0.5 × mic lzd (D) Isolate 1 1 1 × mic fos + 0.5 × mic lzd (E) Isolate 1 0.5 × mic fos + 1 × mic lzd (F) Isolate 1 0.5 × mic fos + 0.5 × mic lzd (G) Isolate 2 1 × mic fos + 0.5 × mic lzd (H) Isolate 2 0.5 × mic fos + 1 × mic lzd (I) Isolate 2 0.5 × mic fos + 0.5 × mic lzd (J) Isolate 3 1 × mic fos + 0.5 × mic lzd (K) Isolate 3 0.5 × mic fos + 1 × mic lzd (L) Isolate 3 0.5 × mic fos + 0.5 × mic lzd. Control: no drug; 0 h, concurrent administration group; 2 h, 4 h, 6 h, 8 h, sequential administration group, interval time.
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Bactericidal activity of fosfomycin and linezolid administered simultaneously or sequentially against <t>mrsa</t> in Static-concentration time- kill studies. Different dose, <t>(A)</t> <t>43300</t> 1 × mic fos + 0.5 × mic lzd (B) 43300 0.5 × mic fos + 1 × mic lzd (C) 43300 1 0.5 × mic fos + 0.5 × mic lzd (D) Isolate 1 1 1 × mic fos + 0.5 × mic lzd (E) Isolate 1 0.5 × mic fos + 1 × mic lzd (F) Isolate 1 0.5 × mic fos + 0.5 × mic lzd (G) Isolate 2 1 × mic fos + 0.5 × mic lzd (H) Isolate 2 0.5 × mic fos + 1 × mic lzd (I) Isolate 2 0.5 × mic fos + 0.5 × mic lzd (J) Isolate 3 1 × mic fos + 0.5 × mic lzd (K) Isolate 3 0.5 × mic fos + 1 × mic lzd (L) Isolate 3 0.5 × mic fos + 0.5 × mic lzd. Control: no drug; 0 h, concurrent administration group; 2 h, 4 h, 6 h, 8 h, sequential administration group, interval time.
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Bactericidal activity of fosfomycin and linezolid administered simultaneously or sequentially against mrsa in Static-concentration time- kill studies. Different dose, (A) 43300 1 × mic fos + 0.5 × mic lzd (B) 43300 0.5 × mic fos + 1 × mic lzd (C) 43300 1 0.5 × mic fos + 0.5 × mic lzd (D) Isolate 1 1 1 × mic fos + 0.5 × mic lzd (E) Isolate 1 0.5 × mic fos + 1 × mic lzd (F) Isolate 1 0.5 × mic fos + 0.5 × mic lzd (G) Isolate 2 1 × mic fos + 0.5 × mic lzd (H) Isolate 2 0.5 × mic fos + 1 × mic lzd (I) Isolate 2 0.5 × mic fos + 0.5 × mic lzd (J) Isolate 3 1 × mic fos + 0.5 × mic lzd (K) Isolate 3 0.5 × mic fos + 1 × mic lzd (L) Isolate 3 0.5 × mic fos + 0.5 × mic lzd. Control: no drug; 0 h, concurrent administration group; 2 h, 4 h, 6 h, 8 h, sequential administration group, interval time.

Journal: Frontiers in Microbiology

Article Title: Enhanced efficacy of sequential administration of fosfomycin and linezolid against methicillin-resistant Staphylococcus aureus

doi: 10.3389/fmicb.2025.1511707

Figure Lengend Snippet: Bactericidal activity of fosfomycin and linezolid administered simultaneously or sequentially against mrsa in Static-concentration time- kill studies. Different dose, (A) 43300 1 × mic fos + 0.5 × mic lzd (B) 43300 0.5 × mic fos + 1 × mic lzd (C) 43300 1 0.5 × mic fos + 0.5 × mic lzd (D) Isolate 1 1 1 × mic fos + 0.5 × mic lzd (E) Isolate 1 0.5 × mic fos + 1 × mic lzd (F) Isolate 1 0.5 × mic fos + 0.5 × mic lzd (G) Isolate 2 1 × mic fos + 0.5 × mic lzd (H) Isolate 2 0.5 × mic fos + 1 × mic lzd (I) Isolate 2 0.5 × mic fos + 0.5 × mic lzd (J) Isolate 3 1 × mic fos + 0.5 × mic lzd (K) Isolate 3 0.5 × mic fos + 1 × mic lzd (L) Isolate 3 0.5 × mic fos + 0.5 × mic lzd. Control: no drug; 0 h, concurrent administration group; 2 h, 4 h, 6 h, 8 h, sequential administration group, interval time.

Article Snippet: A total of three MRSA blood isolates and the methicillin-resistant Staphylococcus aureus strain ATCC 43300 were obtained from the Bacterial Resistance Centre of the First Affiliated Hospital of Anhui Medical University.

Techniques: Activity Assay, Concentration Assay, Control

Simultaneous or sequential administration of fosfomycin and linezolid against mrsa with time-kill curves in a dynamic PK/PD model. (A) 43300; (B) Isolate 1; (C) Isolate 2; (D) Isolate 3. Control: no drug; 0 h, concurrent administration group; 2 h, 4 h, 6 h, 8 h, sequential administration group, interval time. Control: no drug; 0 h concurrent administration group; 2 h, 4 h, 6 h, 8 h, sequential administration group, interval time.

Journal: Frontiers in Microbiology

Article Title: Enhanced efficacy of sequential administration of fosfomycin and linezolid against methicillin-resistant Staphylococcus aureus

doi: 10.3389/fmicb.2025.1511707

Figure Lengend Snippet: Simultaneous or sequential administration of fosfomycin and linezolid against mrsa with time-kill curves in a dynamic PK/PD model. (A) 43300; (B) Isolate 1; (C) Isolate 2; (D) Isolate 3. Control: no drug; 0 h, concurrent administration group; 2 h, 4 h, 6 h, 8 h, sequential administration group, interval time. Control: no drug; 0 h concurrent administration group; 2 h, 4 h, 6 h, 8 h, sequential administration group, interval time.

Article Snippet: A total of three MRSA blood isolates and the methicillin-resistant Staphylococcus aureus strain ATCC 43300 were obtained from the Bacterial Resistance Centre of the First Affiliated Hospital of Anhui Medical University.

Techniques: Control